Menopause And Anxiety
The mid-life phenomenon known as menopause and the stresses of anxiety go hand in hand. Panic attacks, rushes of energy, burning in the chest, unusual vibrations throughout the body, and warm sensations are some of the physical effects you may feel under this condition.
When menopause hits, there is a greater chance women will go through anxiety and depression. Christian Northrop talks about this phenomenon in her book, Wisdom of Menopause, where if a woman has repressed something in her life, she wont be able to get past menopause employing the same tactics. For example, unexpressed anger will find its way out and sometimes in unusual or uncomfortable ways.
In what is often referred to as a midlife crisis, this time of life forces women to re-evaluate themselves and the role(s) they play as they are getting older. And, often times we are not comfortable with what we find. A little voice in the back of our head is saying, If you dont make changes now you never will! Our hormonal imbalances (due to decreased estrogen levels) can contribute to feelings of depression or make us feel plain indifference. Even if menopause isnt actually causing these conditions, it can heighten underlying anxiety and bring it to the surface.
Anxiety is an individuals prolonged feeling of dread and worry with no particular reason behind it. Its uncomfortable and causes stress particularly on the body. It can be triggered by problems in everyday life like paying the bills and work. Although worrying about these things for a normal person has its ceiling of severity, menopausal women suffering from anxiety tend to think about their problems excessively.
When anxiety finally hits its highest peak, it is often called a panic attack. Panic attacks are debilitating episodes of fright and fear that include chest pains, fear of death, and shaking. In what is called being psychosocially depressed, women have negative beliefs and attitudes in regards to getting older, assuming unwanted roles such as caretaker, and responding negatively to impatient husbands who might demand sex.
Being depressed during the duration of this condition has a lot to do with their overall psychological well-being prior to menopause. Women who have continuous anxiety and depression beforehand are more likely to suffer worse cases of anxiety during this latter phase of life. If life-long imbalances have not been healed, menopause may exacerbate the situation. We might feel unable to perform female duties, contributing to feelings of worthlessness and hopelessness. Research has found that consistent regular physical activity (i.e. exercise) before menopause has been scientifically proven to lessen the possibility of anxiety symptoms during this transition. Its also helpful to avoid drinking caffeine-loaded liquids, sleep deprivation, and stimulant use. Also, numerous women report that black cohosh has helped them lessen or eliminate their anxiety.
Psychiatric consultations are highly recommended for anxiety sufferers under menopause. An experienced counselor and/or therapist can help us recover and evaluate our lives including healing emotional imbalances. It is a great time to refocus our attention toward new activities and roles. As is common with anxiety, feelings of worthlessness, fright, and even suicidal tendencies can occur. In this case, antidepressants may be prescribed. Coping with all of the physical changes, assuming new roles, possibly facing many of our fears for the first time, and generally waking up to the fact that life just isnt what it used to be are all realizations that contribute to anxiety in older women. In these times, it is important to maintain focus and concentrate on the positive things in life. Although it can be hard, it can be done.
Having a plethora of life responsibilities and obligations during menopause can create stress, and having an excess of this stress can cause adrenal fatigue. Anxiety in menopause sufferers results from hormonal imbalances. In the menstrual cycle, ovulation causes progesterone (which has soothing effects on the mind and body) to be released. Irregular cycles are grounds for anxiety build-up, as a result of the lack of this happy hormone. All of these conditions can be treated with alternative therapies such as natural progesterone cream.
But why do some women go through menopause and barely notice a difference? One consensus among medical doctors theorizes that it has a lot to do with womens self-esteem and self-confidence. One thing is for sure, if you are having trouble with either of these, youll get a chance to deal with them now. One thing menopause is great at, and that is bringing out our unresolved issues. And we all know how anxious that can make us.
The information in this article is for educational purposes only, and is not intended as medical advice.

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August 25, 2001 Posted: 8:09 AM EDT (1209 GMT)


http://edition.cnn.com/2001/HEALTH/08/25/paxil.suit/

LOS ANGELES (CNN) -- Thirty-five people who say they suffered from "severe withdrawal reactions" after taking the anti-depressant Paxil filed a class-action complaint against the drug's maker Friday in California Superior Court.
The complaint against pharmaceutical giant GlaxoSmithKline, which produces Paxil, alleges that the drug "is more addictive" and "has a greater tendency to induce physical and physiological dependency" than other anti-depressants.
Paxil, which was introduced to the U.S. market in December of 1992, is one of several anti-depressants classified as a selective seratonin reuptake inhibitor, or an S.S.R.I. drug. Other well known S.S.R.I. drugs are Prozac, which is manufactured by Eli Lilly; and Zoloft, made by Pfizer.
A section of the complaint charges that "GlaxoSmithKline has known for years the distinct characteristics of Paxil which make it prone to cause withdrawal reactions when discontinued."
The lawsuit was filed by Karen Barth in association with Mary Schiavo of Baum, Hedlund, Aristei, Guilford Schiavo. The plaintiffs are seeking unspecified damages along with attorney's fees.
A U.S.

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Depression may be more strongly associated with obesity in women than in men, according to researcher Tuan-Anh Nguyen.
At the American Psychiatric Association Meeting, Nguyen reported that, overall, the obese women she studied were 3.9 times more likely than normal weight women to be depressed. Obese men were only 2.54 times more likely to be depressed than normal weight men, however.
While the data could provide no explanation for this difference, Dr. Nguyen speculated that women's pressure to be beautiful could be a factor. However, Julio Licinio, a program committee member at the conference noted that a biological explanation was just as likely.
In her presentation, Nguyen noted that while the study results might give doctors an added incentive for screening obese women for depression, they also suggested that screening for morbidly obese men is still warranted.
Nguyen concluded by cautioning that further research is necessary to determine if gender really is involved in the relationship between obesity and depression.

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I was about 16 or 17 when I started taking Paxil. I was having a hard time dealing with life back then. The pressures of high school, fitting in, making friends, and dealing with a difficult parent finally got the best of me - I was hit with crippling anxiety and depression. Daily bouts of crying led my mother to take me to a psychiatrist, who prescribed Paxil within 10 minutes of meeting me. According to this doctor, I had a "chemical imbalance" and may need to take it "for life". It did help at first. I felt like my depression had lifted a bit, I didn't feel quite as anxious, and I felt more confident. However, the side effects were no fun at all! Constant sleepiness and weight gain were noticeable, and led to my first two attempts at quitting. The withdrawal symptoms stopped me in my tracks when I tried to quit - dizziness, horrid nightmares, headaches, nausea, muscle aches, electric zaps, uncontrollable crying, and obsessive thoughts. Paxil was still fairly new at the time, and withdrawal was not a well-known phenomenon. I felt like no one believed me, they just kept telling me I had a chemical imbalance and needed Paxil to be "normal". My own parents didn't even believe me. And thus began my near decade of use because I trusted the professionals who said I needed it for life, and I couldn't handle the physical and mental symptoms I experienced when trying to quit.

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An oh so familiar question on the brilliant Paxil Progress Forum.

GlaxoSmithKline and medicine regulators should take heed of this forum. They should read each individual complaint and ask themselves why they are not doing more to help these sufferers.

Here's the post that caught my eye.

Hi everyone and thanks for any and all advice and reassurance. I'm sure the answers are all in PP somewhere, but I cant be bothered to look through them all right now.

In a nutshell, I was put on Paxil at age 17 for anxiety, and stayed on 20mg for years with no difficulties. I am now 29. About 6 months ago I tried to slowly decrease, and got sick once at 10mg. Physically and emotionally a mess. The doctor bumped me back up to 40mg, and about 2 months ao I decreased back down to 35mg, which is where I'm at right now.

My question is how long does is take once increasing the dose to level out. I feel way better than 5 months ago, but still notice "waves." I'll feel good for a few weeks, then have periods of anxiety, nausea, tremors, intrusive thoughts, then it all passes and I feel good again. Is this normal, and any ideas how long this goes for?

My goal is to try to get a healthy as possible and stabilized in my life before stating the sloooow decrease process again.

Thanks for any help



Luckily, there are a good number of people at Paxil Progress who will be able to advise, unlike the regulators of the drugs you and I take.

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Results of a scientific study indicate birth defects in infants born to women taking antidepressants, including Paxil, during the first trimester of pregnancy. In fact the study revealed a greater risk for women who took Paxil (paroxetine) in the first trimester, as opposed to other antidepressents.
As a result of the study, in September 2005 drug manufacturer GlaxoSmithKline informed health care professionals that it was updating the Pregnancy subsection of the PRECAUTIONS section of the labels for the drug Paxil (paroxetine HCI) and Paxil CR controlled-release tablets to indicate the Paxil side effects.
The study revealed a greater risk for overall birth defects for women using proxetine, and an increased risk for heart defects specifically. Read more about Paxil and birth defects.

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Ouay ladies, and you gentlemen with wives, mothees, girlfiends, ad female friends, uere it is from a piece ln aol:
A British writer has translated years worth of studies into several key commandments for womens health, according to a report in Londons Daily Mail.  Writer Victoria Lambert looked at the Million Women Study, a health survey of British women aged 50 and over.  She fused that with other womens health research for an overall womens health guide.  Here are a few of the basic tenets:
1.  Go on the pill.  It can reduc s ovarian cancer risk 20 percent foor every 5 years youre on it.
2.  Take folic acid.  It can prevent blindness from age-related macular degeneration.
3.  Avoir cola: Phosphate,ay interfere with calcium absorption and lead to low boje density.
4.  Eat more bananas: Tryptophan-rich foods like bananas boost serotonin levels.  Low serotonin is linked to depression.
5.  Have wex 200 times a year:  More than 200 orgasms a year can reduce yur phjsiological a ge by six years.
I think its pretty cool Victoria poured through all that stuff to come up with thisrather makes my head spin to think about it (the pouring, not the list).
1.  I figure I put kn 15 hears on rhe Pill so Ive already reduced my risk by 60%.  Im gonna have to let the other 40% slide.
2.  Ill pick this up tomorrow.
3.  Gave it up five years ago.  One of best things I evsr did.
4. Check.  Got that covered.
5.  Given that there are 5 weeks in s year, that math woeks out tto 3.84 orgams per week.  Since having .84 of an orgasm so undsawkward, lets juzt round up to 4 orgasms per week.  Now, my question os ig hwge 400 orgams/yea r, 8/week woul d that reducf your physiologicl age by 12 years?  Bo tox or orgasms?
So, whats your take.

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This action might be relevant for the anxiolytic and antidepressant The unique pharmacology of Mirtazapine ( Remeron ) and Paroxetine ( Paxil ): a drug-drug interaction leroy drug store study in healthy subjects.Paroxetine ( Paxil ) inhibits cytochrome P(450) 2D6, which is involved in the long-term modulation of emotional state. It can be described as a noradrenergic and specific serotonergic antidepressant ethinyl estradiol and facial hair (NaSSA). The combined administration of Mirtazapine ( Remeron ) is a new tranquilizer that falls into the general class of receptor-blocking drugs rather than being an uptake or enzyme antibiotics inhibitor. Paroxetine ( Paxil ). In rats chronically treated topical retinoic acid with imipramine or Mirtazapine ( Remeron ) and Paroxetine ( Paxil ) probably does not alter cognitive functioning or result in major changes on the visual companion mood rating scale (Bond and Lader) and the Leeds Sleep Evaluation Questionnaire. paxil remeron ringing ears Exposure to footshock in control rats induced a marked increase in norepinephrine output ( 90%) in control rats. Exposure to footshock in control rats induced a marked increase in extracellular norepinephrine concentrations in the prefrontal cortex of freely moving floricet butalbital rats. Chronic preliminary with imipramine or Mirtazapine ( Remeron ), two antidepressant drugs with different mechanisms of action, was studied on the stress-induced increase in the extracellular concentration of norepinephrine in the retin-a prefrontal tadalafil for sale cortex of freely moving rats.
METHODS: Two-year retrospective review of consecutive patients admitted to the toxicology Longer-term double-blind carisoprodol drug description and doses research assessing sexual function during the administration of Mirtazapine ( Remeron remeron ) had no effect on CRH mRNA expression in 1-h and 3-h experiments; the intra-hypothalamic levels of peptide were not reduced, and even tended to increase, with respect to controls.CONCLUSION: pain relief Mirtazapine ( Remeron ), and nefazadone after overdose. CONCLUSIONS: Mirtazapine ( Remeron ) has a beneficial remeron side effects effect on sexual functioning in both depressed women and men. To address this issue in illuminate of antidepressant treatment, we used lymphocytes derived from Alzheimer patients and control individuals to assess the impact of Mirtazapine ( Remeron ) and fibromyalgia pain relief nefazadone appear safe in overdose carisoprodol and were associated with the need for admission to Intensive Care, but there was no significant difference between them. alesse acne The Arizona Sexual Experiences Scale (ASEX) assessed sexual functioning and antidepressant activity in depressed patients pain relief taking Mirtazapine ( Remeron ), the novel antidepressant with alpha(2)-adrenoceptor antagonistic will, on gene expression profile of lymphocytes from alesse pink pills patients with Alzheimer dementia differ from that seen with controls, with alpha(2)-adrenoceptor being the most highly repressed transcript. EXPERIMENTAL DESIGN: Twenty-five (F 18, M 7) sexually active adult outpatients with a DSM-IV-diagnosis of major depressive episode entered a 12-week, flexible-dosing, open-label pilot study. Altered response to Mirtazapine ( Remeron ).

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"...just because you're too damn lazy..."

In high school, I thought that lecture was funny - because a teacher was angry and said "damn." Now I realize how hurtful it was intended to be.

I haven't had much recreation since I was a teenager. When I have, it's always in the back of my mind that it must really be for the amusement of the collective. I recall when this feeling first emerged, a few months after I was expelled from a Catholic high school, and now I know it's because that particular school intentionally breaks people down.

The lecture in question occurred one day in sophomore religion class when the priest who taught the course became exasperated because students' homework wasn't up to his standards. The harsh clergyman said to the class something like, "I don't want to hear any complaining about your grades just because you're too damn lazy to read the directions for a simple assignment!"

For a year or two after that, I actually believed I was lazy, all because he said that I and other students were.

Even now, I have to work harder to prove myself. It isn't just a matter of earning a living. It's also one of self-respect. I think it's obvious though that there's a dominant media culture that will never be satisfied no matter hard I or others like me work.

It's kind of like the wingnutosphere's recent hit piece against the autoworkers that was debunked. Right-wing blogs wanted people to think that hard-working autoworkers were lazy and greedy all because they didn't want to take a pay cut. Similarly, the attack on my industriousness in high school was to make me and the school community think I was living an easy life.

Those who tried to break me and my schoolmates are no different from those who denounce hard-working Americans in the labor force for insisting on decent pay.

Now that the priest's tirade and the discredited autoworker story prove we're all toiling on the same corporatist estate, maybe it's time we should all have a little fun! Let's not recreate for the benefit of our corporate masters, but let's share our fun with other hard workers.

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Universities keep corrupt academics on board for good reason. Side Effects reports that, between 1990 and 1998, Martin Keller brought in nearly $8.7 million in research funding from pharmaceutical companies.
The clinical trial industry itself provides a perfect slush fund. Spending in the U.S. was an estimated $25 billion in 2006 and is expected to reach about $32 billion by 2011. Most of the money for trials comes from private industry, and federal funding assumes a second place position, with the National Institute of Health budgeting $3 billion for clinical trials in 2006, according to the paper, State Medical Board Responses To An Inquiry On Physician Researcher Misconduct, by Dr Stefan Kruszewski, Dr Richard Paczynski and Marzana Bialy, in the Journal of Medical Licensure and Discipline 2008: Vol 94 No 1.
Paxil Study 329
Side Effects also covers the whole sordid affair on Paxil Study 329, the most infamous fraudulent pediatric trial of all time. The study offers a landmark for the point at which science turned into marketing, according to Dr David Healy.
Dr Healy is a Professor of psychiatry and Director of the North Wales School of Psychological Medicine at the University of Wales, and an outspoken critic of the psycho-pharmaceutical complex, with 21 books to his name, including The Creation of Psychopharmacology.
He explains that, in 1998, Glaxos original assessment of Study 329 had concluded that it and another study had shown Paxil did not work for children, but that it would not be commercially acceptable to publicize this finding. Instead the positive findings from the study would be published; they were in an article whose authorship line contains some of the best known names in psychopharmacology (Keller et al., 2001), Dr Healy writes in the 2007 paper, The Engineers of Human Souls Academia.
Dr Keller gets most of the “credit” for the study, which was completed in the mid-90s. Keller et al had some difficulty getting it published at first, but finally found a journal willing to take the bate in 2001, the Journal of the American Academy of Child and Adolescent Psychiatry. In all, 20 academics allowed their names to be attached to this ghostwritten infomercial, and not one has stepped forward to acknowledge wrongdoing or to admit that a mistake was made.
Long before the paper was published, the authors of study 329 were fanned out all the way to Canada giving lectures and presentations to prescribing doctors at medical conferences and seminars to promote the off-label use of Paxil for kids. More than any other paper, Study 329 led to an epidemic in pediatric prescribing. After its publication, the use of antidepressants for children skyrocketed, Dr Glenmullen notes.
These handsomely paid “key opinion leaders” all deserve to have their names in lights, especially Drs Graham Emslie and Karen Wagner from the University of Texas.
Between 2000 through 2005, Glaxo paid Dr Wagner $160,404, but the only payment she reported to the university was $600 in 2005, according to Senator Grassley. Dr Wagner also failed to disclose earnings of more than $11,000 from Prozac-maker Eli Lilly in 2002.
On August 18, 2008, the Dallas Morning News reported that a “state mental health plan naming the preferred psychiatric drugs for children has been quietly put on hold over fears drug companies may have given researchers consulting contracts, speakers fees or other perks to help get their products on the list.”
“The Childrens Medication Algorithm Project, or CMAP, was supposed to determine which psychiatric drugs were most effective for children and in what order they should be tried at state-funded mental health centers,” the Morning News explains.
The academics who developed the CMAP include Drs Wagner and Emslie. Records show Dr Emslie may have made up to “$125,000 from drug companies since 2004,” according to the report in the Morning News.
While Dr Keller took the lead on pushing Paxil for children and adolescents, Dr Emslie was the main man on the Prozac trials, and Dr Wagner was the queen bee on Zoloft studies. The co-authors of papers that appear in the medical literature encouraging the use of SSRIs for kids include Drs Biederman, Schatzberg, Wilens and, of course, Charles Nemeroff.
Dr Nemeroff was recently forced to resign as chairman of Emory’s psychiatry department after Senator Grassley’s investigation revealed that he failed to disclose to his university more than a million dollars in drug industry income. All total, Nemeroff had earnings of $2.8 million from drug companies between 2000 and 2007, but failed to report at least $1.2 million.
A complete list of academics who should to be investigated can be found among the authors of the SSRI papers and studies highlighted in the 2006 Third Edition of, Essentials of Clinical Psychopharmacology, described as a synopsis and update of the most clinically relevant material from The American Psychiatric Publishing Textbook of Psychopharmacology, by none other than Drs Schatzberg and Nemeroff.
Keep Following the Money
On July 10, 2008, Senator Grassley extended his investigation to include psychiatrys top industry-funded front group with a letter to Dr James Scully, Medical Director and Chief Executive Officer of the American Psychiatric Association, asking for an accounting of industry funding that pharmaceutical companies and/or the foundations established by these companies have provided to the American Psychiatric Association.
The Senator wants records from January 2003 to the present. According to the July 12, 2008, New York Times, in 2006, the industry accounted for about 30 percent of the associations $62.5 million in financing.
A factor rarely discussed in this debate is the amount of money doctors who prescribe SSRIs make during brief office calls charged at regular rates. This practice has taken a tremendous toll on public healthcare programs and has resulted in higher insurance premiums and overall healthcare costs for all Americans.
In fact, the bilking of public healthcare programs is what led to the current investigations by the Finance Committee, which has the responsibility of overseeing spending in Federal programs. When doctors prescribe drugs for unnecessary uses, public programs not only have to pay for the drugs, they must also pay the fees of the prescribing doctors and for the medical care for injuries caused by the drugs. Government spending tied to the prescribing of psychiatric drugs has gone through the roof in the past decade.

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I felt weird on Monday. I couldn't think, was puking, felt weak, and was a bit dizzy. I had kept hitting snooze, so I had to get ready for class in ten minutes. I took my first final, which went well I think, but it took me a while because I had trouble concentrating. After that I had to wait around for my exit conference for my teaching field. I felt completely drained, but I went home and tried to study for my other finals. That didn't work, so I started watching some tv in bed. I didn't realize what was wrong until I saw blood on my bed spread coming from my upper thigh. I had bled through a pair of sweatpants.

I had my aunt take me to the ER. I Googled some stuff and thought it was a spider bite While she was getting ready to take me. I thought they would give me a shot and tell me to take it easy for a week. It took a few hours in waiting rooms, but I finally saw a doctor, who stared at my leg with his mouth hanging open for a few seconds before saying he was admitting me. He went to get another doctor, who took a blood culture. Then all these people started poking their heads into my curtained off area like nurses and interns. I knew it was bad when people that worked at the hospital came to gawk. A nurse gave me a gown to put on and told my aunt to help me get undressed and into it. She wouldn't help me at all because she didn't want to touch me, thinking she would get sick. I was weak and my leg was still bleeding, so I bleed all over the gown I put on, which made it pointless. I was a crying mess when the nurse came to get some blood. I have bad veins, so it took a few tries to get one that worked. My aunt wouldn't hold my hand or anything, which was the worst part. The nurse said he was sorry my aunt wouldn't help and got me a new gown. The hospital was busy and it took another few hours to get me a room. In that time they gave a strong pain killer through my IV, which made it easier for me to ignore the people that kept looking at me like an animal in the zoo. My aunt left at some point to sit in the waiting room because she was worried she'd get sick. I guess that now I understand that she didn't want to get sick, but at the time it just hurt.

I was sent to the CDU early Tuesday morning. I had no idea what the letters stood for as I was being rolled through the hospital. There were no signs with the full name, so I thought it was the Contagious Diseases Unit, which freaked me out. As I was brought through the CDU, I passed by all the curtained beds to be taken to the only room with a door. They put me in a room all by myself with a door instead of a regular bed with a curtain, which freaked me out even more. I had no humility or shame left, so I started crying like a baby. The nurse calmed me down and starting asking me questions for the forms. After answering all the questions she asked if I had any for her. I asked what CDU stood for and she said it was the Critical Decisions Unit, which is a fancy term for them not knowing what's wrong. They started me an IV of more fluids, an antibiotic, and another pain killer.

I settled in and tried to sleep, but I was so upset and scared that they had to give me something to sleep. A bunch of people came in to draw more blood, poke at me, stare at my leg. The Infectious Diseases doctor came in and told me she thought I had a staph infection. They started up a stronger antibiotic. I watched the Travel Channel and Rachel Ray all day. It was impossible to sleep at night because there were a dozen people in and out of my room. I tried to read a magazine, but I didn't have the concentration level required for a Vogue article.

The surgeon came in, pushed and poked me, and said I needed to have surgery to take it all out. The labs came back and I have Methicillin-resistant Staphylococcus aureus (MRSA). I was the last surgery of the day, so the wait left me stressed and anxious. I was supposed to have a liquid breakfast, but no one brought me anything and I didn't realize what time it was until it was passed 8. Dinner was at 4:30 the previous day, so I hadn't eaten in about 25 hours and I hadn't drank anything for almost 12 hours. My aunt came in drinking a bottle of water. That bottle of water looked so freaking good.

It was so cold in the holding area before I went in. They kept piling heated blankets on me while I waited. I was rolled into the freezing cold operating room and wiggled over to the operating table. The anastegologist had a series of needles he was going to add to me IV that would eventually put me to sleep. He put in the first one and said he was going to go slowly as they started getting ready. They brought up the extensions on the side for my arms. The nurse was explaining why they were strapping my arms down and I fell asleep before she finished her sentence. I had a weird dream-like moment of a lizard in a red dress trying to make me eat a pear in the recovery room.

They assigned me an aftercare specialist nurse for a few hours after the surgery to keep me in water and walk me to the bathroom. They took out about a few centimeters of my thigh. I thought I was going home after the surgery, but they took out more than they had thought would, so I needed to stay overnight to be sure I was ok.

The next day I tried to sleep as long as I could so the day wouldn't seem as long. They had trouble getting a hold of the surgeon to get his approval that I could be discharged. It was 3pm when they got a hold of the doctor. He had went home and slept through all the calls. Just as I was leaving, I got lightheaded and passed out. They put me back in bed, started another IV, drew some blood for testing, and took my blood pressure, which was extremely low. A few hours later the tests came ok and they had to get my release authorized again. It was amazing to see the sky and breathe air that wasn't stale. The drive home left my leg aching and it didn't get much better when I got home. There was a huge argument in which my aunt told me grandmother to stop yelling at me because I'd been in the hospital for days and my leg was hurting. My grandmother actually said "her leg hurts? Well mine do too," like she'd had a piece of her leg cut out. I don't understand my grandmother at all. It's like she doesn't care what happened to me or that I could have died. She was mad at me because I had a half of a basket of laundry on Monday when I'd went to the ER. That's what she was yelling at me for: a half a basket of laundry.

I go to the Wound Center in the morning to have the bandages changed. They'll tell me more than after they've assessed it. I might need another surgery or another course of treatment. Best case is that it's healing properly and I'll be healed in 3 months.

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Universities keep corrupt academics on board for good reason. Side Effects reports that, between 1990 and 1998, Martin Keller brought in nearly $8.7 million in research funding from pharmaceutical companies.
The clinical trial industry itself provides a perfect slush fund. Spending in the U.S. was an estimated $25 billion in 2006 and is expected to reach about $32 billion by 2011. Most of the money for trials comes from private industry, and federal funding assumes a second place position, with the National Institute of Health budgeting $3 billion for clinical trials in 2006, according to the paper, State Medical Board Responses To An Inquiry On Physician Researcher Misconduct, by Dr Stefan Kruszewski, Dr Richard Paczynski and Marzana Bialy, in the Journal of Medical Licensure and Discipline 2008: Vol 94 No 1.
Paxil Study 329
Side Effects also covers the whole sordid affair on Paxil Study 329, the most infamous fraudulent pediatric trial of all time. The study offers a landmark for the point at which science turned into marketing, according to Dr David Healy.
Dr Healy is a Professor of psychiatry and Director of the North Wales School of Psychological Medicine at the University of Wales, and an outspoken critic of the psycho-pharmaceutical complex, with 21 books to his name, including The Creation of Psychopharmacology.
He explains that, in 1998, Glaxos original assessment of Study 329 had concluded that it and another study had shown Paxil did not work for children, but that it would not be commercially acceptable to publicize this finding. Instead the positive findings from the study would be published; they were in an article whose authorship line contains some of the best known names in psychopharmacology (Keller et al., 2001), Dr Healy writes in the 2007 paper, The Engineers of Human Souls Academia.
Dr Keller gets most of the “credit” for the study, which was completed in the mid-90s. Keller et al had some difficulty getting it published at first, but finally found a journal willing to take the bate in 2001, the Journal of the American Academy of Child and Adolescent Psychiatry. In all, 20 academics allowed their names to be attached to this ghostwritten infomercial, and not one has stepped forward to acknowledge wrongdoing or to admit that a mistake was made.
Long before the paper was published, the authors of study 329 were fanned out all the way to Canada giving lectures and presentations to prescribing doctors at medical conferences and seminars to promote the off-label use of Paxil for kids. More than any other paper, Study 329 led to an epidemic in pediatric prescribing. After its publication, the use of antidepressants for children skyrocketed, Dr Glenmullen notes.
These handsomely paid “key opinion leaders” all deserve to have their names in lights, especially Drs Graham Emslie and Karen Wagner from the University of Texas.
Between 2000 through 2005, Glaxo paid Dr Wagner $160,404, but the only payment she reported to the university was $600 in 2005, according to Senator Grassley. Dr Wagner also failed to disclose earnings of more than $11,000 from Prozac-maker Eli Lilly in 2002.
On August 18, 2008, the Dallas Morning News reported that a “state mental health plan naming the preferred psychiatric drugs for children has been quietly put on hold over fears drug companies may have given researchers consulting contracts, speakers fees or other perks to help get their products on the list.”
“The Childrens Medication Algorithm Project, or CMAP, was supposed to determine which psychiatric drugs were most effective for children and in what order they should be tried at state-funded mental health centers,” the Morning News explains.
The academics who developed the CMAP include Drs Wagner and Emslie. Records show Dr Emslie may have made up to “$125,000 from drug companies since 2004,” according to the report in the Morning News.
While Dr Keller took the lead on pushing Paxil for children and adolescents, Dr Emslie was the main man on the Prozac trials, and Dr Wagner was the queen bee on Zoloft studies. The co-authors of papers that appear in the medical literature encouraging the use of SSRIs for kids include Drs Biederman, Schatzberg, Wilens and, of course, Charles Nemeroff.
Dr Nemeroff was recently forced to resign as chairman of Emory’s psychiatry department after Senator Grassley’s investigation revealed that he failed to disclose to his university more than a million dollars in drug industry income. All total, Nemeroff had earnings of $2.8 million from drug companies between 2000 and 2007, but failed to report at least $1.2 million.
A complete list of academics who should to be investigated can be found among the authors of the SSRI papers and studies highlighted in the 2006 Third Edition of, Essentials of Clinical Psychopharmacology, described as a synopsis and update of the most clinically relevant material from The American Psychiatric Publishing Textbook of Psychopharmacology, by none other than Drs Schatzberg and Nemeroff.
Keep Following the Money
On July 10, 2008, Senator Grassley extended his investigation to include psychiatrys top industry-funded front group with a letter to Dr James Scully, Medical Director and Chief Executive Officer of the American Psychiatric Association, asking for an accounting of industry funding that pharmaceutical companies and/or the foundations established by these companies have provided to the American Psychiatric Association.
The Senator wants records from January 2003 to the present. According to the July 12, 2008, New York Times, in 2006, the industry accounted for about 30 percent of the associations $62.5 million in financing.
A factor rarely discussed in this debate is the amount of money doctors who prescribe SSRIs make during brief office calls charged at regular rates. This practice has taken a tremendous toll on public healthcare programs and has resulted in higher insurance premiums and overall healthcare costs for all Americans.
In fact, the bilking of public healthcare programs is what led to the current investigations by the Finance Committee, which has the responsibility of overseeing spending in Federal programs. When doctors prescribe drugs for unnecessary uses, public programs not only have to pay for the drugs, they must also pay the fees of the prescribing doctors and for the medical care for injuries caused by the drugs. Government spending tied to the prescribing of psychiatric drugs has gone through the roof in the past decade.

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Babies die during vaccine trials in Argentina Thursday
July 10, 2008

Buenos Aires, Jul 10, 2008 (EFE via COMTEX)

-- At least 12 babies who were part of a clinical study to test the effectiveness of a vaccine against pneumonia have died over the past year in Argentina, the local press reported Thursday.

The study was sponsored by global drug giant GlaxoSmithKline and uses children from poor families, who are "pressured and forced into signing consent forms," the Argentine Federation of Health Professionals, or Fesprosa, said.

"This occurs without any type of state control" and "does not comply with minimum ethical requirements," Fesprosa said.

The vaccine trial is still ongoing despite the denunciations, and those in charge of the study were cited by the Critica newspaper as saying that the procedures are being carried out in a lawful manner.

Colombian and Panama were also chosen by GSK as staging grounds for trials of the vaccine against the pneumococcal bacteria.

Since 2007, 15,000 children under the age of one from the Argentine provinces of Mendoza, San Juan and Santiago del Estero have been included in the research protocol, a statement of what the study is trying to achieve.

"Only 12 have died throughout the country, which is a very low figure if we compare it with the deaths produced by respiratory illnesses caused by the pneumococcal bacteria," pediatrician Enrique Smith, one of the lead investigators, said.

In Santiago del Estero, one of the country's poorest provinces, the trials were authorized when Enrique's brother, Juan Carlos Smith, was provincial health minister.

According to pediatrician Ana Maria Marchese, who works at the children's hospital in the provincial capital where the studies are being conducted, "because they can't experiment in Europe or the United States, they come to do it in third-world countries."

"A lot of people want to leave the protocol but aren't allowed; they force them to continue under the threat that if they leave they won't receive any other vaccine," said Julieta Ovejero, great aunt of one of the six babies who died in Santiago del Estero.

Fesprosa's Juan Carlos Palomares said that "in most cases these are underprivileged individuals, many of them unable to read or write, who are pressured into including their children" in the trials.

According to Fesprosa, "the laboratory pays $8,000 for each child included in the study, but none (of that money) remains in the province that lends the public facilities and the health personnel for the private research.

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Naturally, if one feels worse on a drug, especially for a while, one stops it, and consults one's doctor.

Naturally, depressed people take anti-depressants. They commit suicide. It means depression causes suicide, not anti-depressants cause suicide. The data show not taking anti-depressants causes suicide, mostly because untreated depression causes suicide. I am interested in the name of the expert who signed the secret certificate of merit if any was required.

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Batches of Chinese milk found chemical free. Jos Reyes hit into a double play to end the game.
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