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The plaintiffs law firm that sought mass-tort status, Douglas London of New York, maintains that the litigation will likely involve thousands of cases with the same defendants, similar complex issues of law and fact, and plaintiffs with a high degree of commonality in their injuries and damages.
The firm, which has filed six Levaquin suits in New Jersey, also said Atlantic County is appropriate because its docket is less crowded than those in Bergen or Middlesex counties, the other venues hearing mass-tort cases.
Continue reading "Litigation Over Johnson Johnson Antibiotic Levaquin Designated N.J.
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That drug absolutely ruined my life, says the 61year-old Oxnard woman, who was given Cipro and its sister drug, Floxin, for a urinary tract infection in 1996. She blames the drugs for causing blurred vision, excruciating muscle and joint pain and a cascade of other disabling side effects that have left her unable to work or even play with her grandchildren.
The former election technician for Ventura County says, I never in a million years thought an antibiotic could do this to me. It makes me heartsick watching people on TV grabbing up Cipro when theyre not even sick and letting themselves in for so many adverse reactions that their doctors may not even recognize.
Yet thousands, if not millions, are grabbing up Cipro. In recent weeks, public health officials have prescribed the drug to thousands of postal workers, congressional staff members and others possibly exposed to anthrax. And countless more Americans have purchased Cipro on their own, wanting it on hand just in case they develop symptoms of the potentially lethal infection. Cipros German-based manufacturer, Bayer, says it has cranked up production to make 200 million pills within 60 days, enough to treat 12 million people.
The tremendous potential for misuse of this powerful drug has some health professionals worried. The very strengths that make Cipro and other fluoroquinolone antibiotics such as Levaquin and Floxin so effective against serious infection also raise their potential for severe side effects. If Americans who have hoarded Cipro decide to inappropriately self-medicate at the first sign of a cold during the upcoming flu season, drug experts say, they will needlessly expose themselves to the risk of an alarming array of adverse reactions.
Although its not widely recognized, Cipro and other fluoroquinolones are associated with serious, rapid side effects that can be devastating and sometimes permanent, says Dr. Jay S. Cohen, an associate professor of family medicine at UC San Diego.
Two kinds of side effects are most commonly linked with fluoroquinolones: musculoskeletal problems such as tendinitis, tendon rupture and joint pain, and central nervous system problems such as insomnia, hallucinations, depression and paranoia. Less well-known are the adverse reactions that affect the peripheral nervous system, such as tingling, burning pain, twitching or spasms, Cohen adds.
Adverse reactions to fluoroquinolones are often simply overlooked-blamed on other factors, for example, says Cohen, who contends that the drugs are much riskier than is widely believed. He has written a report, scheduled for publication in the December issue of the Annals of Pharmacotherapy, documenting severe sensory disturbances associated with fluoroquinolones. Baldwin is one of 45 patients cited in the study.
Although warnings about most of the drugs side effects are listed in the Physicians Desk Reference, Cohen says, many patients reported that their doctors either failed to recognize the adverse events or dismissed their significance. They were told to continue taking the drug, when its imperative that someone with these reactions discontinue use immediately unless medical circumstances such as severe infection and no alternative treatment-warrant otherwise.
Public Health Concerns
In recent weeks, public health officials have been struggling to inform Americans that antibiotics other than Cipro such as doxycycline and penicillin are effective against anthrax and to urge them not to take any antibiotic without the specific advice of a physician and a clear indication that exposure to the organism may have occurred. All antibiotics can cause gastrointestinal disturbances such as stomach upset and diarrhea-and kill good bugs in the body, setting the stage for problems such as yeast infections and the growth of drug-resistant bacteria. Yet penicillin and doxycycline are less risky than Cipro, whose very strength makes its side effect profile much wider.
Cipro is basically a big gun whose benefits outweigh its risks in certain circumstances, says David Flockhart, chief of clinical pharmacology at the Indiana University School of Medicine. He is considered by many to be the countrys foremost expert in fluoroquinolone-related side effects. But the bigger gun you use, the more damage you can expect as collateral. For a variety of reasons from anthrax hysteria to incentives from drug companies Flockhart says some physicians start with the big gun rather than the lower-level antibiotics, such as penicillin, which can be just as effective, less expensive and less risky.
Fluoroquinolones should absolutely not be given to kids or pregnant women, says Flockhart, since they can interfere with bone growth. Cipro and other fluoroquinolones also have been associated with ruptures of the shoulder, hand and Achilles tendons that required surgical repair or resulted in prolonged disability. This prompted the Food and Drug Administration in 1996 to ask manufacturers to add a warning to package inserts advising patients to discontinue treatment, inform their physicians and refrain from exercise if they experience pain, inflammation or tendon rupture. Some sports medicine specialists now say they avoid prescribing fluoroquinolones to athletes.
Incidence of Side Effects
Although there are no firm figures on how many people have suffered tendon rupture or any other serious adverse reaction to Cipro, the accepted range for common side effects from any drug is 5% and for uncommon side effects is less than 1%, says Daniel AIbrant, a spokesman for the American Pharmaceutical Assn. and president of the health care consulting firm Pharmacy Dynamics in Arlington, Va. This mean that, for every million people who take Cipro, as many as 10,000 might experience the less common-and often most serious-side effects.
One of Cipros strengths is its ability to penetrate the central nervous system, says Flockhart, who adds that the downside is that this increases the risk of adverse psychological reactions. About 30% of patients given intravenous Cipro and about 10% of those who take oral Cipro tablets may experience psychological side effects, he says. These range from feeling out of it to being anxious and jittery to, in extreme cases, having seizures.
These adverse reactions generally go away when the drug is stopped, says Flockhart, who notes that, in rare cases, an underlying psychiatric concern may be exacerbated by the drug and persist.
One of the best known of these cases is the experience of Philadelphia fiction writer Diane Ayres, who in 1992 took a single Floxin tablet that her physician prescribed for a minor urinary tract infection and wound up delirious in the emergency room six hours later.
She is now diagnosed with manic-depressive illness triggered by the powerful antibiotic, for which she has been treated with medication for nine years, says her husband, investigative journalist Stephen Fried. Fried chronicled his wifes struggle as friendly fire in the war on disease in the 1998 book Bitter Pill: Inside the Hazardous World of Legal Drugs.Cipro is the quintessential kind of drug that people take like candy because they think all drugs are safe, says Fried, whose original article probing drug safety for Philadelphia magazine received the 1994 National Magazine Award and set off a Food and Drug Administration investigation. With so many horrible things going on in this world, some people want to believe that if they take this pill, it will protect them. But thats not how it works, and what people dont understand is that these drugs can cause illness.
Mortality of Adverse Drug Reactions
More than 100,000 Americans die each year from adverse drug reactions, making legal drugs the fourth-leading cause of death in the United States, Fried notes. Yet the general public and some physicians often dont consider the risks versus the benefits when selecting medication, he says. Certain people may be at greater risk of experiencing adverse reactions to fluoroquinolones, including the elderly, people with existing psychiatric or neurological symptoms or a history of head trauma, impaired kidney function and those taking certain medications, including caffeine and nonsteroidal anti-inflammatories such as ibuprofen. Fatal reactions have occurred in patients taking Cipro with the asthma drug theophylline.
A lot of people get these drugs for the most minor infections, says Fried. But there are a lot of people who should think twice before taking a quinolone for anything.
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Antibiotics can be the problem, not the remedy.
Quinolones are currently the most commonly prescribed class of antiobiotics. They are very powerful medications used to treat many types of infections such as respiratory infections, urinary tract infections, and sinus infections. The two most commonly prescribed quinolones are Levaquin and Cipro. Like all medications this class of antibiotics has side effects. However, what differentiates this class of antibiotics from others is that quinolones have the ability to cause severe and permanent disability. Many of these side effects can even occur weeks to months after taking the antibiotic. Approximately half of the quinolones that were once on the market have now been removed from clinical practice due to their severe toxicities. Examples include Tequin, Omniflox, Trovan, and Zagam.
There is no question that quinolone antibiotics have their usefulness. They are extremely powerful medications that work very well to kill difficult to treat infections. They have proved to be life saving in certain situations. However, they were never meant to be used as a first line of defense against mild infections which is how they are often prescribed today. This leads to bacterial resistance.
In July of 2008, the FDA mandated that all quinolone antibiotics carry a “Black Box “ warning for tendon rupture and tendonitis. This is the strongest warning label a drug can have before it is removed from the market. Public Citizen, a consumer advocacy group, sued the FDA demanding quinolones carry a Black Box warning. If Public Citizen had not taken this action there may not be any “Black Box” warning for this class of antibiotics. The FDA gets approximately 50% of their funding for the review of drugs directly from the pharmaceutical companies in what is called prescription drug user fees. This is an absurd conflict of interest that has made the FDA very slow and often reluctant to react to drug toxicities of all kinds. What the FDA is doing and what the public thinks the FDA is doing is as different as night and day- A quote from Dr. Herbert Ley, former commissioner of the FDA. If you look closely at the track record of the FDA it would indicate that they are serving interests other than yours and mine. In 2007, China executed Zheng Xiaoyu, who was the head of the food and drug administration in that country for taking $800,000 of money from the drug companies. In America, this behavior seems to be simply business as usual.
Dr. David Graham, from the FDA, says that the Vioxx debacle alone caused more than 60,000 deaths. To put that in perspective, that is more deaths than the number of American troops that died in the Vietnam war. Since the major media outlets obtain considerable advertising revenue from the drug industry they are often reluctant to do a story on the damaging side effects of medications. They don’t like to bite the hand that feeds them.
Unfortunately, the Black Box warning is far too late for the thousands of people that are now living with devastating disabilities. Hundreds of US media and postal workers who took Cipro during the 2001 anthrax scare claim they suffered permanent nerve and tendon damage. Some of the many websites that describe the severe adverse reactions to quinolones include: Antibiotics.org, Favc.info, Fqhelp.com, Fqvictims.org, Fqresearch.org, and the very detailed Fluoroquinolones.org
Dr. Jay Cohen, a medical researcher and associate professor at the University of California, San Diego published a paper on severe peripheral neuropathy caused by quinolones. Dr. Cohen mentions that these debilitating reactions are not rare. He mentions that most doctors have dismissed patient complaints or outright deny that quinolones can cause this type of long term damage even though it is mentioned in the package insert. Even if one person in 100 suffers a grave side effect that can still mean millions of people affected. Even the FDA admits that less than 10 % of all adverse drug reactions ever get reported to their agency.
David Flockhart, professor of medicine and chief of clinical pharmacology at Indiana University School of Medicine, says as many as a third of patients taking a quinolone will experience some sort of psychiatric side effect, such as anxiety, personality change, or confusion. “ The psychiatric effects of the quinolones are underappreciated by the medical profession as well as by the public,” says Dr. Flockhart, who has treated more than one hundred patients with severe psychiatric side effects.
I personally feel the number of people affected by this toxicity is the medical equivalent of an Enron. Before anyone takes this class of antibiotics they should have the right to know that it can cause irreversible damage. People need to be afforded the right of informed consent. The prescribing literature patients receive at the pharmacy is far different than what is in the tiny print in the package insert. Why am I writing an article on quinolone antibiotics? I feel that I have a moral obligation to warn as many people as possible. Over three and a half years ago I was prescribed Levaquin for a possible infection and like tens of thousands of others my life has been turned into a living hell. I write this article in the hopes of preventing others from suffering a similar fate.
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Ive had chronic recurring epididymitis ever since I was young which was usually treated with anti-inflamatories just to come back later. I was prescribed 500mg of Cipro for 3 weeks in fall 2005 even though I didnt have any signs of infection. As soon as I had finished the course my foot swelled up with gout and I was unable to walk. I went to urgent care and asked if it couldve been caused by the medicine they said no. A week later I went to urology because I was still having pain. Again I asked about the connection between gout and the medicine. I was told no again and prescribed Levaquin for a month which didn’t work either. Later I was told by another urologist that the swelling could indeed have been caused by the medicine
The pain resolved on its own after several months in spring 2006 and I was ready to get back to life. I had gone back to school because I wanted to get a degree, join the military as an officer and then come back and teach PE. That summer I started getting earaches. I had no infection and was diagnosed with a Eustachian tube disorder. 1 week later the headaches started. It was so bad I thought I had meningitis and was going to die. I wanted to cry so much from the pain. My neck hurt and was stiff. I couldn’t keep my head up straight nor keep my eyes open. My head pounded and burned. I had increased pressure and the outside of my head hurt to touch and my sinuses burned. At one point I even passed out and was taken to the hospital. I had a CT scan done and was told I had a sinus infection. I was given antibiotics but this time a different kind (Probably amoxicillin.) That didn’t work as well. So then they changed their diagnosis to allergic rhinitis. Went to a neurologist
who ordered an MRI which came back negative as well. Gradually this pain went away as well. The headaches still return a couple times a month although not as severe.
Then In Fall 2006 the joint pain started. At first, It was just my shoulders and my back which I thought were related to weight lifting. So I stopped for awhile but the pain didn’t go away. Next, the knee pain started. They were stiff, popped a lot, and when I would take a step I would get a sharp pain which made it feel like my knee had locked up. X-rays were performed which showed know damage. I was sent to physical therapy for six months which only aggravated the symptoms. Later pain showed up in other areas such as my Achilles, feet, elbows, hips and wrists. I have seen two orthopedists and a rheumatologist. One orthopedist didn’t believe me. MRIs were done of both knees know damage shown. The other has heard about the damage but says its just case reports and that what’s done is done. He tried to reassure me by saying if anything is ever damaged he can fix it. Rheumatologist said that antibiotics can cause autoimmune disorders and performed a lot of blood tests all
of which were negative or within range. He then sent me to genetics thinking I might have Marfan’s which I don’t have either. I contacted him following my genetics appointment and was told he didn’t have anymore tests to perform so not to come back.
I have all the typical symptoms of the reactions to the medication. Joint pain, joint popping, numbness, tingling, spasms/twitches, headaches, eye pain, eyes burn, always tired, always cold. I’m sure some things have even slipped my mind. I can’t get anyone to look at even part of the Flox report. Most recently I’ve been diagnosed with Seborrheic Dermatits and I get coldsore outbreaks around my mouth every two weeks when I used to get them about twice a year.
I have no idea what I am supposed to do. My whole life is on hold. I can’t work. We pay more than $500 a month for health insurance because of all the appointments due to medicine I was prescribed. I’m 26 years old I haven’t been able to workout or play sports in years. My girlfriend left me, she didn’t feel like I could protect her anymore, and said I wasn’t man enough and wanted some one she could kiss. My mom wants me out. My “friends” just say I’m getting old or need to workout and eat more. I am completely out of time and out of options. How can I get a job like this? How can I get MY job like this? I shouldn’t have to compromise. I just pray that one day soon I’ll be strong enough to end my suffering and that people will regret not taking me seriously.
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I talked a school teacher a few weeks ago. She hasnt been able to work for about a year now from her quinolone poisoning. I think she is improving to the point of now going back to work part time which is very good news. I talked to her her husband and he had to take so much time off work to help care for her. They have spent a ton of money trying to get her better not to mention the all of the lost wages. I have gotten so many emails from quinolone victims where they have said that their spouse either doesnt fully believe or has a very difficult time believing that an antibiotic could do this long term damage. I wonder what ever happened to DB Cipro- Death by Cipro blog. He would often mention his wife didnt believe this toxicity. I hope he is still alive. I wonder what percentage of families have been ruined because of innocent victims that have suffered moderate to severe poisonings. That is the part of this toxicity that is never really measured. The financial toll from being unable to work, large medical bills ect. can easily ruin a family. It is such a terrible shame. The drug companies sweep everything under the rug because their only resposibility is to maximize shareholder return. And in doing that they need to cover this toxicity up as much as possible. More awareness leads to less prescriptions leads to less profit.
Bob G. once told me that one of his friends told his sister Is Bob still talking about that Cipro thing. That is the way it was put- That Cipro thing Comments like that just illustrate the lack of understanding of this toxicity. All of us that have been moderately or severely poisoned are living in a physical and or neurological inferno. The passage of time seems to be the only way out for most of us. These defective antibiotics have far reaching effects that permeate into the rest of the family unit that causes their lives to be very difficult as well. It is hard to believe that these drug companies that know all this dont really care at all. No conscious. They look into a mirror and the only thing looking back is an empty soul and a large bank account.
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.Six years ago while undergoing chemotherapy for breast cancer, my doctor presecibed Levaquin as a for any infection. Preventive??? Within 24 hours I was in severe burning pain all over my neck, arms and legs. I did not associate this with the Levaquin at the time as I had also received chemo drugs. I took a round of 10 pills that first month, all the time getting worse with the pain. Next round of chemo I had been doing some research and knew it was not the chemo drugs but something else. I took 7 pills that round. By round 3, I was having hear palpitations and had to be hooked up to a heart monitor, could not walkmore than a few steps, was having excruciating pain in all my joints, and continued with the severe burning pain. Round 4 I took no Levaquin as by then I had figured out it was that drug causing my problems. I saw a neurologist who had never heard of this reaction before (he has now!). He did all sorts of tests and determined I had peripheral neuropathy
and prescribed neurontin, which now has been switched to Lyrica. It helps somewhat with the burning pain. By now, he has told me it is irreversible. I was at the point of suicide during that first year, having the note and plan all figured out. My family is what I have been living for. The things that have helped me are: switching to organic meat, esp. chicken as most chickens are treated with this antibiotic, drinking and cooking only with non-floridated water. I have to be careful of drinking any fountain drinks at restaurants as they use local water mixed with the fizz. There are many days still of horrible pain in all my joints, head pressure so bad I want to die, burning pain all over even in my mouth and throat. Accupuncture did not help, meditation did not help, increased exercise did not help. I wish someone would have warned me of this horrible drug. I beat cancer, but I cant beat the effects of this wicked drug. I truly will pray for all out there afflicted with these side effects. Please hang in there. I almost didnt.
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Levaquin levofloxacin is part of the fluoroquinolone group of oral medications prescribed to treat acute bacterial sinusitis, acute bacterial exacerbation of chronic bronchitis, noscocomial pneumonia, community-acquired pneumonia, complicated skin and skin structure infections, mild to moderate uncomplicated skin and skin structure infections, chronic bacterial prostates, urinary tract infections and acute pyelonephritis caused by Escherichia coli, also known as E. coli, which is an infection affecting the lower intestines of humans and highly associated with food poisonings in the United States. The drugLevaquin, which is manufactured by from pharmaceutical firm Ortho-McNeil, was approved in 1996, but the oral solution was introduced in 2004 and this was followed by a 750-milligrams (mg) five-day oral treatment becoming widely available in 2005, although the Levaquin is also available intravenously as well.
While Levaquin is prescribed for an array of bacterial infections, it has also been approved to treat the effects of airborne anthrax. It was also recently approved for the use by in treating children as an anti-bacterial component and as a treatment of anthrax contamination among children as well. The drug is absorbed quickly, particularly after oral consumption and is usually allotted in 500 mg to 750 mg doses.
According to manufacturers, individuals who have kidney disease, diabetes, spinal or brain cord conditions are highly recommended to avoid the drug as it could cause serious side eaffects including:
* slow absorption of in kidney disease patients
* blood level spikes and irregularities of in diabetes patients
* uncontrollable seizures among spinal and brain injury patients
Levaquin Side Effects
According to manufacturers, the most common adverse drug reactions Levaquin side effects that occurred in U.S. individuals who underwent a Levaqin clinical trial experienced insomnia and dizziness as well as diarrhea, nausea and constipation. Additionally, the list of side effects continues to grow and patients thatwith exude any of the following symptoms should stop taking the medication and seek medical assistance immediately:
* abdominal tenderness, cramping or severe pain
* confusion, hallucinations or psychosis
* diarrhea (which may be bloody)
* fever
* blisters, redness and swelling of the skin
* sensation of burning skin
* trembling or seizures
* vomiting
* easy bruising or bleeding
* jaundice
* numbness in limbs, tingling in fingers
* swelling, pain in legs/muscles
Recent studies have also suggested that individuals with preexisting conditions (previously mentioned) as well as individuals taking specific types of medicine may increase their risk of these Levaquin side effects causing severe medical trauma.
Complications may occur when use of Levaquin is combined with:
* blood thinners (warfarin/coumadin)
* cyclosporine
* insulin
* theophylline
* aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs)
* heart rhythm medications (Cordarone, Pacerone, etc.)
* antacids (Tums, Rolaids)
* ulcer medication (Carafate)
* didanosine (Videx)
* vitamins or supplements containing iron or zinc
Levaquin Tendon Rupture Risks
The most serious Levaquin side effect is the risk of Achilles tendonitis among current and former patients of Levaquin levofloxacin. Several studies published in accredited medical journals including the Journal of Antimicrobial Chemotherapy, The Journal of the American Board of Family Medicine, The Annals of Pharmacotherapy and Tthe Journal of Orthopaedics and Traumatology have all cited case studies in which individuals who have taken Levaquin have been adversely affected by levofloxacin-induced tendonopathy and tendon rupture.
According to the report from The Journal of American Board of Family Medicine, the onset of tendon ruptures among patients characteristically is abrupt in onset causing extreme sharp pains and swelling of legs when walking. The study also reports that while most of the tendonitis among Leva
quin patients occurs within the first two weeks of taking the drug., Hhowever, it can occur in patients long after the drugs cycle has been completed.
In some patients, the Levaquin tendon ruptures occurred longer than six months after treatment administration of the drug. The study noted that the U.S. Food and Drug Administration (FDA) found that in 1991, tendon rupture could be a risk of quinolone drugs.
Although it wasnt until 1996 when the FDA issued its first Report of adverse Events on the fluoroquinolones. In a 10-year period, at least 200 reports of Achilles tendonitis have occurred in association with Levaquin. Additionally, a report from the United Kingdom found that levofloxacin-induced tendonitis potentially affects approximately 3.2 out of approximatly every 1,000 Levaquin patients who have taken the drug at some point.
Victims of Levaquin Risks
Individuals who have previously been exposed totaken Levaquin, whether through intravenous or oral methods, should speak with their physician to asses any potential risk. Additionally, patients may which to consult with an experienced Levaquin lawyer a pharmaceutical lawyer especially if any of the previous symptoms have occurred. Additionally, because of the severity of tendonitis and potential long-term damage done, it is important for an individual to consider seeking out compensation in the form of a Levaquin Lawsuit that may provide monetary relief from the extensive surgical and medical procedures likely associated with solving or easing the pain of tendonitis caused through a prescription of Levaquinby having taken Levaquin.
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The doctor wrote that the reason for the QEEG test was to provide objective data and clarification about my current level of neurophysiological functioning in reference to my history of acute debilitating symptoms regarding my central nervous system. He mentioned that the QEEG test was seen as a measure of functional brain activity that could be used to guide subsequent therapeutic interventions.
Specific findings in my QEEG test.
Finding #1
He shows a persistent highly significant over activation of Beta 2 and Beta 3 and Gamma wave activity in the right prefrontal area. Gamma activity is also high centrally and in the left frontal area. This finding is at a significant level in the eyes closed state and is much less noticeable when his eyes are open or reading.
Interpretation: The elevation of Beta and Gamma frequencies in the eyes closed state is most likely related to his reported insomnia and pattern of obsessive worry and ruminating thoughts. The observation that this area increases in fast wave activity when the eyes are closed indicates that when he tries to relax a paradoxical effect takes place that results in increased arousal of cognitive activity associated with emotional hypervigilance and awareness of danger. Individuals with this pattern often experience high levels of anxiety and panic states which correspond to his symptoms that he is reporting. The increase in Gamma activity in the central and left frontal areas is likely related to patterns of physical pain. It is likely that his nervous system has how to stand down and that he operates with chronic fatigue as the result of sleep deprivation.
Finding # 2 He shows an elevation in Theta wave activity in the occipital and right temporal areas. This finding is seen in all three conditions but is most significant when he attempts to read.
Interpretation: This finding unquestionably relates to his visual processing problems. The acute presentation of this symptom and the focal nature of the EEG pattern suggests this is related to some specific toxic exposure with local impact or a traumatic event. This high level of focal theta may also be related to his balance problems since the occipital area can reflect activity originating in the cerebellum which is responsible for balance and equilibrium.
Finding #3 A pattern of suppressed power in the occipital area is present across all frequencies. This deficit is noted using Laplacian montage which adjusts for artifacts in electrical recording found in other statistical programs. This deficit in absolute power is very evident in the eyes closed and eyes open conditions but is somewhat attenuated but still present in the reading condition.
Interpretation: The suppression in electrical energy in the occipital region relative to a normal population is consistent with a toxic reaction or metabolic disorder that is centralized in the visual processing area of the brain. In the absence of any other systemic illness in his history the likely cause for this toxic reaction is the Levaquin exposure.
The fact that theta wave activity also increases in the occipital area when attempting to read suggests that although he attempts to mobilize energy to read, his brain is not able to produce a functional state that supports this goal. In other words when attempting to read his brain attempts to marshall energy for this task but ends up producing a pattern of electrical activity associated with dysfunction. Findings # 2 and # 3 should therefore be seen as supporting the hypothesis of significant impairment on both a functional and metabolic level to the occipital region of the brain and potentially to the cerebellum as well.
The constellation of factors found in his record suggest that he is similar in his QEEG profile to those individuals who have difficulty learning and retaining new information. Given the nature of his symptoms and his successful premorbid adjustment it is likely that his similarity to a learning impaired population is related to his Levaquin exposure.
That is pretty much the bulk of what my QEEG test showed. It took me a ton of time to type this up. I could have typed this so much faster pre-Levaquin. It is very hard to find a practioner to do a QEEG test. These are not considered standardized tests. Many doctors are not even familiar with these tests. I only had one done because I was told that there is a high probability that they will show damage since some other quinolone victims have had them done and they have showed damage. I needed some sort of documentation for social security disability purposes. It is hard to accept that I have so much damage to my brain. The doctor suggested neurofeedback as a potential treatment option. If anybody is interested in having a QEEG test done it is best to probably QEEG or quantitative EEG test and the town or city and the state you live in to find practitioners that do these brain mapping tests. The test was painless. It mainly consisted of various electrodes strapped to my brain. The results are then generated into some sort of computer software brain mapping program. Bobs QEEG test is what he used for his social security disability documentation.
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The doctor wrote that the reason for the QEEG test was to provide objective data and clarification about my current level of neurophysiological functioning in reference to my history of acute debilitating symptoms regarding my central nervous system. He mentioned that the QEEG test was seen as a measure of functional brain activity that could be used to guide subsequent therapeutic interventions.
Specific findings in my QEEG test.
Finding #1
He shows a persistent highly significant over activation of Beta 2 and Beta 3 and Gamma wave activity in the right prefrontal area. Gamma activity is also high centrally and in the left frontal area. This finding is at a significant level in the eyes closed state and is much less noticeable when his eyes are open or reading.
Interpretation: The elevation of Beta and Gamma frequencies in the eyes closed state is most likely related to his reported insomnia and pattern of obsessive worry and ruminating thoughts. The observation that this area increases in fast wave activity when the eyes are closed indicates that when he tries to relax a paradoxical effect takes place that results in increased arousal of cognitive activity associated with emotional hypervigilance and awareness of danger. Individuals with this pattern often experience high levels of anxiety and panic states which correspond to his symptoms that he is reporting. The increase in Gamma activity in the central and left frontal areas is likely related to patterns of physical pain. It is likely that his nervous system has how to stand down and that he operates with chronic fatigue as the result of sleep deprivation.
Finding # 2 He shows an elevation in Theta wave activity in the occipital and right temporal areas. This finding is seen in all three conditions but is most significant when he attempts to read.
Interpretation: This finding unquestionably relates to his visual processing problems. The acute presentation of this symptom and the focal nature of the EEG pattern suggests this is related to some specific toxic exposure with local impact or a traumatic event. This high level of focal theta may also be related to his balance problems since the occipital area can reflect activity originating in the cerebellum which is responsible for balance and equilibrium.
Finding #3 A pattern of suppressed power in the occipital area is present across all frequencies. This deficit is noted using Laplacian montage which adjusts for artifacts in electrical recording found in other statistical programs. This deficit in absolute power is very evident in the eyes closed and eyes open conditions but is somewhat attenuated but still present in the reading condition.
Interpretation: The suppression in electrical energy in the occipital region relative to a normal population is consistent with a toxic reaction or metabolic disorder that is centralized in the visual processing area of the brain. In the absence of any other systemic illness in his history the likely cause for this toxic reaction is the Levaquin exposure.
The fact that theta wave activity also increases in the occipital area when attempting to read suggests that although he attempts to mobilize energy to read, his brain is not able to produce a functional state that supports this goal. In other words when attempting to read his brain attempts to marshall energy for this task but ends up producing a pattern of electrical activity associated with dysfunction. Findings # 2 and # 3 should therefore be seen as supporting the hypothesis of significant impairment on both a functional and metabolic level to the occipital region of the brain and potentially to the cerebellum as well.
The constellation of factors found in his record suggest that he is similar in his QEEG profile to those individuals who have difficulty learning and retaining new information. Given the nature of his symptoms and his successful premorbid adjustment it is likely that his similarity to a learning impaired population is related to his Levaquin exposure.
That is pretty much the bulk of what my QEEG test showed. It took me a ton of time to type this up. I could have typed this so much faster pre-Levaquin. It is very hard to find a practioner to do a QEEG test. These are not considered standardized tests. Many doctors are not even familiar with these tests. I only had one done because I was told that there is a high probability that they will show damage since some other quinolone victims have had them done and they have showed damage. I needed some sort of documentation for social security disability purposes. It is hard to accept that I have so much damage to my brain. The doctor suggested neurofeedback as a potential treatment option. If anybody is interested in having a QEEG test done it is best to probably QEEG or quantitative EEG test and the town or city and the state you live in to find practitioners that do these brain mapping tests. The test was painless. It mainly consisted of various electrodes strapped to my brain. The results are then generated into some sort of computer software brain mapping program. Bobs QEEG test is what he used for his social security disability documentation.
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The Food and Drug Administration in March approved the use of ciprofloxacin, or Cipro, for some kidney and urinary tract infections in children under 18, in the event other antibiotics failed to work.
And two clinical trials are under way to demonstrate that another drug, Levaquin, is a safe and effective treatment for pneumonia and middle ear infections in children.
Both Cipro and Levaquin belong to a class of pharmaceuticals called quinolones. The drugs, which include Avelox, Tequin, Floxin and others, have been hailed as life-saving medications that often work when other antibiotics have failed. Hundreds of millions of doses are prescribed every year.
After anthrax spores were released in Florida, New York, Washington, D.C., New Jersey and Connecticut in the fall of 2001, the Centers for Disease Control and Prevention recommended that more than 10,000 people take Cipro as a safeguard.
Johnson Johnson Corp., which markets Levaquin through its subsidiary, Ortho-McNeil Pharmaceuticals Corp., reported to the Securities and Exchange Commission that Levaquin sales last year were over $1 billion.
But those positive figures, and the risk-benefit calculations that led the FDA to move to open pediatrics markets to quinolones, do not impress thousands of people who say they have suffered adverse reactions from the drugs.
There are people who are sitting ducks, waiting to have the side effects of these drugs, which are very effective antibiotics that work often for millions of other people, said Dr. David Flockhart, chief of the Division of Clinical Pharmacology at Indiana University School of Medicine.
Adverse side effects either listed by quinolone manufacturers on drug labels or reported to the FDAs Adverse Events Reporting System include moderate to abnormal sensitivity to light, grand mal seizures, heart arrhythmia, toxic psychosis and ruptured tendons.
s pure evil, said John Angell, a Senate staffer who had Achilles tendon injury after taking Cipro in the aftermath of the 2001 anthrax attack.
The fact that quinolones can damage tendons in adults has led some experts to worry about the impact they may have on growing cartilage in children.
Flockhart recalls examining a teen-age girl from the Chicago suburbs after she had been given Levaquin four years ago for a condition that was diagnosed as a sinus infection.
The 35-page FDA-approved label for Levaquin, also known by the generic term levofloxacin, contains the following warning:
The safety and efficacy of levofloxacin in pediatric patients, adolescents under the age of 18 years, pregnant women and nursing women have not been established.
The Chicago teen-ager is one of 81 persons from 1 to 17 years old whose adverse reactions to Levaquin, Cipro or Floxin appear in the FDAs adverse events data base.
These reactions ranged from nausea to coma and cardiac failure, according to the data base. The side effect listed, without explanation, for one 16-year-old girl was
The Chicago teen-ager was also 16 when a physician told her mother to give her Levaquin, according to the girls sister.
The sister, Mrs. Teri Noto of Roselle, Ill., said the teen-ager did not get through the full course of daily 500-milligram Levaquin pills.
After five days, it was as if a bomb went off in her body, said the sister. She collapsed at school and had to be half-carried out of the building.
Noto said her sister had been a talented musician, artist and athlete, advancing to within a few points of a black belt in Tae Kwon Do karate.
The girl, now 20, can walk only a short distance at a time, according to her sister. She attends college and gets around on an electric scooter.
She has had 29 orthopedic casts to prevent tendon rupture in her arms and legs, her sister said, and the hands that once played the piano and executed the swift movements of karate are often too weak to pick up a book.
More than 2,000 children with pneumonia or ear infections will be receiving Levaquin in trials being sponsored by Johnson Johnson Pharmaceutical Research Development Corp.
The ongoing pneumonia trials stopped recruiting subjects two weeks ago. Children age 6 months to 5 years are still being recruited for the otitis media, or ear infection, trial.
The purpose of that trial is to compare the effectiveness and safety of Levaquin with another antibiotic, Augmentin, according to information posted on a government Web site, clinicaltrials.gov.
Dr. Edward Goldblatt, an Alabaster, Ala., pediatrician, said he signed up to participate in the trial but withdrew because it required so much time. He said he hoped the trial succeeded, because we need another antibiotic for this condition.There are some antibiotic-resistant pneumonias and ear infections in children that can be most severe, he said. Some of them are resistant to just about anything we can give by mouth.
Ortho-McNeil spokespersons said the company organized clinical trials of Levaquin for pediatrics use at the request of FDA.
They said that because of growing bacterial resistance to drugs, the agency is eager to increase the number of antibiotics available for use in children.
In addition to the warning that Levaquin has not been shown to be safe for children, the drug label states that experiments on immature animals of several species showed that it and other quinolones harmed cartilage and eroded weight-bearing joints.
Ortho-McNeil spokeswoman Leslie Fishman said concern that quinolones might hinder the growth of cartilage in children was based solely on these animal studies.
There was concern at the outset, but there has never been a report of cartilage damage in a child, she said. Based on the available data, it (the early concern) did not pan out.
She provided a paper published this year by scientists from Israel, Costa Rica and Switzerland, all of whom disclosed that they receive research funding from Johnson Johnson or other pharmaceutical companies that produce quinolones.
The paper concluded that cartilage damage by quinolones is a laboratory phenomenon in juvenile animals and has not been documented in children who were given the drugs because of hard-to-treat infections.
FDA officials declined to answer questions on the record about the issue of quinolones and children. Speaking on background, an official said the agency faces a complicated decision in the matter.
The fact that laboratory studies show cartilage deformation in juveniles from several species, including rats, guinea pigs and dogs, rather than just one species that might have a unique susceptibility, is significant, the official said.
Also, doses used in these experiments were similar to levels that would be given to children.
On the other hand, with growing problems of bacterial resistance to antibiotics and the fact that a child might be allergic to another drug, the agencys scientific advisers have urged it to establish safe quinolone levels as backup drugs for children.
Some doctors dont believe anything should be done to weaken restraints on use of quinolones.
I feel these drugs should be used only by specialists in infectious disease, said Dr. Edward Cooper, a general practitioner who works at a walk-in clinic in San Jose, Calif.
Cooper said the drugs are commonly prescribed as first-line antibiotics when they should not be used in most cases unless other antibiotics have been shown not to work.
The problem is exacerbated, some doctors and researchers say, by errors in prescribing the drug in a climate unduly influenced by the high-pressure sales tactics of pharmaceutical manufacturers.
The drug reps will come by and extol the virtues of the medications and we get mailings every two months about how good these medications are, Cooper said. But they rarely tell doctors about the side effects.I feel that it is like a dysfunctional family where no one is allowed to talk about the fathers drinking problem despite all the evidence to the contrary, he said.
Records that came to light last year in an employment discrimination lawsuit in Chicago depict a sales climate consistent with Coopers observations.
In the suit, lawyers for Ortho-McNeil successfully moved to suppress evidence about the efficacy, appropriate medical use, potential side effects and/or cost of Levaquin.
Minutes of a meeting held in June 2000 and entered as evidence in the trial describe sales representatives being exhorted to push Levaquin.
They were urged to increase their calls to hospital officials, take them to lunch and sponsor office Christmas parties, the minutes show.
They were told to refer to Augmentin (the drug against which Levaquin will be compared in the childrens ear infection trial) as a horse pill and use a large piece of hard candy as an illustration, according to the minutes.
A federal judge directed a jury to rule in favor of Ortho-McNeil in the job discrimination matter and the plaintiff has appealed. Ortho-McNeil spokesman Fishman said the company could not comment about ongoing litigation.
In 1996, Ralph Naders Public Citizen consumer advocate organization petitioned the FDA to require that quinolone labels contain warnings about tendon rupture, a step cautious European regulators already had taken.
Public Citizen requested that the warnings be printed in boldface type and that the agency send a Dear Doctor letter to all physicians, specifically calling their attention to the danger.
The FDA required the warnings on page 15 of the 35-page label and not in boldface type but did not send the letter.
Larry Sasich, a Public Citizen pharmacist who signed the petition, said this was disappointing.
We thought it was necessary to raise a red flag, said Sasich, because who would suspect that you would get tendon rupture from an antibiotic?
He said doctors seldom have time to read lengthy drug
In fact, researchers at the University of Pennsylvania School of Medicine last year analyzed 100 quinolone prescriptions written in a hospital emergency room and found that only one of them was written for the right condition and in the right dosage.
Dr. Ebbing Lautenbach, an epidemiologist, said in an interview that he and the other researchers were primarily concerned not with adverse reactions but by worries that overuse of quinolones would accelerate the development of quinolone-resistant germs.
He said that after analyzing a random prescription for the antibiotic and the 99 subsequent prescriptions for the same quinolone, they found:
In 43 cases, another drug was considered the proper first-line treatment.
In 27, there was no documentation of infection.
In 11, there was no way to assess the need for antibiotics.
In the remaining 19 cases, quinolones were found to have been the correct medication, but only one of these patients received the correct dose for the correct duration.
No one knows how many Americans experience adverse reactions to quinolones each year. The FDA estimates that between one and 10 percent of all adverse drug reactions are reported to its Adverse Events Reporting System.
They say the system is intended to help them spot trends in drug side effects and is not a comprehensive accounting of drug reactions.
Because of the Internet, persons who believe they have been harmed by quinolone side effects are becoming more and more visible. Bound together by Web sites on which they share stories, they have formed a bitter electronic community.
Flockhart is skeptical about some of the self-reported reactions. Such people may have some other problem and until they are examined by a physician trained in clinical pharmacology, no one will know what they have, he says.
Others, he also believes, have quinolone reactions that are misdiagnosed as something else.
Quinolones are really the tip of the iceberg, he said. s the general fact that were not good at recognizing and treating adverse drug reactions in primary care.
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These meds are bad stuff and have caused me so much pain. Why hasn't the FDA pulled this stuff from the shelves? I have been prescribed this medication several times over the past 3 years. I have reoccuring sinus infections and UTI's. These meds are bad stuff and have caused me so much pain. Why hasn't the FDA pulled this stuff from the shelves? I have been prescribed this medication several times over the past 3 years. I have reoccuring sinus infections and UTI's. The FDA added a black box warning to the entire fluoroquinolone class of antibiotics on 7/8/08. More disturbing, I just received a letter in the mail this week notifying me of this change. None of the drug reps mentioned this. No mention was made at the international allergy convention I attended last week either. I have not read about this in any of the journals I read. This fact was not brought up in any of the pharmacy committee meetings or that I attend.
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I am so fatigued from the Levaquin poisoning coupled with the pain medications that I am actually blowing a fan on myself in the winter time to help counteract the lethargy. I seem to be able to eat a slightly wider array of foods now. Still cant get anywhere near soy or soy lecithin. Sugar, msg, meat, poultry, seafood are all off limits. I can eat organic meat but I still sometimes seem to get a little worse on organic meat. I can drink a little organic milk.
I seem to be doing a little worse lately. I think I may have been exposed to some solvents or chemicals because my head pressure has ramped up and I am getting a chalky taste in my mouth. My head pressure was so horrendous in those first years. It always severely escalated when I tried to drive. There must be low level gas fumes in a car that dont effect normal people but when you are floxed like I am it makes the squeezing of my head much worse. I tried three different cars and it is all the same level of escalation of head pressure. This is another one of the numerous bizarre Levaquin poisoning symptoms. I actually had to have my parents get me a thick plastic tube about four feet long from Home Depot and when I would try and drive I would put that in my mouth and have the tube extend out the window so that I would be breathing fresh air. It looks totally ridiculous but it helped cut the head pressure a little. I always get a lot of crazy looks from other drivers. Understandably so. Glad I havent been pulled over by a cop yet. With my head pressure up beyond normal levels now in this latest cycle, I will probably have to bring out the plastic tube again for any driving.
I watched the Quinolone documentary again last night. It is a very good movie but I wish it was more than an hour long. It would have been good to add a few more victims. The website for the movie should be available very soon. There is an domestic commercial airline pilot in the movie who was poisoned by Levaquin. He felt really ill and he couldnt track things correctly visually and had the head pressure that I have. He was flying a domestic flight with a lot of people on board. Unknown to all the passengers was that this pilot was flying a plane while he was poisoned ( floxed ) by Levaquin. If the plane had crashed, the true cause of the crash would never had been known. Quinolone related deaths never get traced back to Levaquin, Cipro, Avelox, ect. There is another film producer in California who has filmed a bunch of Quinolone victims. He is still in the long process of editing his documentary. It is going to be called Invisible People which I think is a very good title. Hopefully this documentary will come out sometime soon. When the Quinolone movie documentary website is finished, I will put it on my blog.
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Rush Limbaugh: 1-800-282-2882 Roughly 20 million listeners.
Sean Hannity: 1-800-941-7326 Roughly 13 million listeners.
Michael Savage: 1-800-449-8255 Roughly 8 million listeners.
Glen Beck: 1-877-727-Beck Not sure how many listeners. His audience is really growing.
The best way to do this is to dial once and just keep hitting the redial button. You can watch Tv and just keep hitting redial button on phone. This way you wont be wasting time.
Some possible Talking Points to make on air on these radio shows:
Need to blame the government. Specifically say that the FDA, which is a government agency, is too blame since they have known about quinolone damage for years. These talk show hosts are all conservative and dont want to hear that the drug companies are at fault. If that happens they will take over the conversation and we wont be able to get in as much about the toxicity of quinolones. This happened to me on Sean Hannity show and that was my mistake.
I think it is best to say Levaquin and Cipro since they comprise the bulk of quinolone prescriptions. If you start adding in all the other quinolones it will take up too much time and it will be harder for the listeners to remember. If one more can be added it should be Avelox. Or say Levaquin, Cipro and other quinolone antibiotics.
Mention that many Levaquin and Cipro victims are in wheelchaiers, crutches, bedridden for many years. W e need to shock the listener as much as possible. Mention about the brain damage that lasts years and is sometimes permanent.
Mention that many symptoms are delayed by weeks and months so many of the victims never link their disabilities to Levaquin and Cipro.
Mention that anybody can check all of this out online on the internet. Type in Cipro poison, Levaquin poison, Levaquin adverse reaction ect.
Mention that hundreds of peoplethat took Cipro during the 2001 Antrax scare claim that they have permanent nerve and tendon damage. There is a good aticle with David Fuller in it called Antibiotics can be the problem, not the remedy.
Mention that Levaquin and Cipro were given a Black Box warning which is the most strict warning that a drug can have before it is pulled from the market and that this class of antibiotics, quinolones, are meant to be prescribed as a last line of defense. Not prescribed indiscriminantly like it is candy which is how they are prescribed today.
Mention that there are multiple doctors that have wrtten articles about these crippling effects that last years. Dr. Cohen, Dr. Flockhart, and Dr. Plumb.
Mention that there is even an article called The Poisoning of America by Jason Uttley that links quinolones to fibromyalgia and chronic fatigue syndrome and that these illnesses started at approximately the same time as the introduction of quinolones. Mention that if anybody listening to this radio show suffers from unexplained pain, insomnia, anxiety, depressed mood, fibromyalgia, and chronic fatigue to check your medical records to see if you were ever given Levaquin, Cipro or Avelox. That would really shock the listener. I think this is what we need. To really shock and alarm the listener to the point that they will go home and research what they heard on the radio. Since there are so many people now that have fibromylagia and chronic fatigue this would be a really poweful point in getting a much greater awareness of quinolone toxicity, less needless prescriptions written for this class of antibiotics, and less people crippled for years.
Another point to add in is that the tens of thousands that are now disabled are a hugh burden to US taxpayers. Many of these victims are now on social security disability and the medical costs to treat all of the disabled people is astronomical costing US taxpayers a lot of money. Talk show hosts love to hear that the government is causing problems.
The points that I mentioned above are just suggestions. Anybody that has been damaged by a quinolone can add in whatever else they think. I am sure everybody can think of some points that are better than what I have listed. If I can get on a big talk show with just a few phone calls so can everyone else. It is not as hard as you think. I think radio is one of the best ways to tell our collective horror story because once you get on the radio it is on the air. Print media advocacy is difficult because they have time to read it and reject it. I think it is also important to butter up the radio talk show host and say you are a big fan of the show, even if youre not. Say governement is the problem and the FDA, a government agency, is the reason tens of thousands are disabled costing the US taxpayers millions in disability and medical costs. This way you will get more time. Again, this is just my slant on what to say on these radio shows. There are also many local talk shows that have considerable audiences. The more that hear about this, the more it will spread and do damage to the people that damaged us.
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Rush Limbaugh: 1-800-282-2882 Roughly 20 million listeners.
Sean Hannity: 1-800-941-7326 Roughly 13 million listeners.
Michael Savage: 1-800-449-8255 Roughly 8 million listeners.
Glen Beck: 1-877-727-Beck Not sure how many listeners. His audience is really growing.
The best way to do this is to dial once and just keep hitting the redial button. You can watch Tv and just keep hitting redial button on phone. This way you wont be wasting time.
Some possible Talking Points to make on air on these radio shows:
Need to blame the government. Specifically say that the FDA, which is a government agency, is too blame since they have known about quinolone damage for years. These talk show hosts are all conservative and dont want to hear that the drug companies are at fault. If that happens they will take over the conversation and we wont be able to get in as much about the toxicity of quinolones. This happened to me on Sean Hannity show and that was my mistake.
I think it is best to say Levaquin and Cipro since they comprise the bulk of quinolone prescriptions. If you start adding in all the other quinolones it will take up too much time and it will be harder for the listeners to remember. If one more can be added it should be Avelox. Or say Levaquin, Cipro and other quinolone antibiotics.
Mention that many Levaquin and Cipro victims are in wheelchaiers, crutches, bedridden for many years. W e need to shock the listener as much as possible. Mention about the brain damage that lasts years and is sometimes permanent.
Mention that many symptoms are delayed by weeks and months so many of the victims never link their disabilities to Levaquin and Cipro.
Mention that anybody can check all of this out online on the internet. Type in Cipro poison, Levaquin poison, Levaquin adverse reaction ect.
Mention that hundreds of peoplethat took Cipro during the 2001 Antrax scare claim that they have permanent nerve and tendon damage. There is a good aticle with David Fuller in it called Antibiotics can be the problem, not the remedy.
Mention that Levaquin and Cipro were given a Black Box warning which is the most strict warning that a drug can have before it is pulled from the market and that this class of antibiotics, quinolones, are meant to be prescribed as a last line of defense. Not prescribed indiscriminantly like it is candy which is how they are prescribed today.
Mention that there are multiple doctors that have wrtten articles about these crippling effects that last years. Dr. Cohen, Dr. Flockhart, and Dr. Plumb.
Mention that there is even an article called The Poisoning of America by Jason Uttley that links quinolones to fibromyalgia and chronic fatigue syndrome and that these illnesses started at approximately the same time as the introduction of quinolones. Mention that if anybody listening to this radio show suffers from unexplained pain, insomnia, anxiety, depressed mood, fibromyalgia, and chronic fatigue to check your medical records to see if you were ever given Levaquin, Cipro or Avelox. That would really shock the listener. I think this is what we need. To really shock and alarm the listener to the point that they will go home and research what they heard on the radio. Since there are so many people now that have fibromylagia and chronic fatigue this would be a really poweful point in getting a much greater awareness of quinolone toxicity, less needless prescriptions written for this class of antibiotics, and less people crippled for years.
Another point to add in is that the tens of thousands that are now disabled are a hugh burden to US taxpayers. Many of these victims are now on social security disability and the medical costs to treat all of the disabled people is astronomical costing US taxpayers a lot of money. Talk show hosts love to hear that the government is causing problems.
The points that I mentioned above are just suggestions. Anybody that has been damaged by a quinolone can add in whatever else they think. I am sure everybody can think of some points that are better than what I have listed. If I can get on a big talk show with just a few phone calls so can everyone else. It is not as hard as you think. I think radio is one of the best ways to tell our collective horror story because once you get on the radio it is on the air. Print media advocacy is difficult because they have time to read it and reject it. I think it is also important to butter up the radio talk show host and say you are a big fan of the show, even if youre not. Say governement is the problem and the FDA, a government agency, is the reason tens of thousands are disabled costing the US taxpayers millions in disability and medical costs. This way you will get more time. Again, this is just my slant on what to say on these radio shows. There are also many local talk shows that have considerable audiences. The more that hear about this, the more it will spread and do damage to the people that damaged us.
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Levaquin levofloxacin is part of the fluoroquinolone group of oral medications prescribed to treat acute bacterial sinusitis, acute bacterial exacerbation of chronic bronchitis, noscocomial pneumonia, community-acquired pneumonia, complicated skin and skin structure infections, mild to moderate uncomplicated skin and skin structure infections, chronic bacterial prostates, urinary tract infections and acute pyelonephritis caused by Escherichia coli, also known as E. coli, which is an infection affecting the lower intestines of humans and highly associated with food poisonings in the United States. The drugLevaquin, which is manufactured by from pharmaceutical firm Ortho-McNeil, was approved in 1996, but the oral solution was introduced in 2004 and that was followed by a 750-milligrams (mg) five-day oral treatment becoming widely serviceable in 2005, although the Levaquin is also realizable intravenously as well.
While Levaquin is prescribed for an array of bacterial infections, it has also tired approved to treat the effects of airborne anthrax. It was also latterly approved for the use by in treating children as an anti-bacterial component and as a treatment of anthrax contamination among children as well. The drug is absorbed quickly, particularly after oral consumption and is usually allotted in 500 mg to 750 mg doses.
According to manufacturers, individuals who have kidney disease, diabetes, spinal or brain cord conditions are highly recommended to avoid the drug as it could cause serious side eaffects including:
* slow absorption of in kidney disease patients
* blood level spikes and irregularities of in diabetes patients
* uncontrollable seizures among spinal and brain injury patients
Levaquin Side Effects
According to manufacturers, the utmost common adverse drug reactions Levaquin side effects that occurred in U.S. clinical trials of Levaquin included headache, nausea and diarrhea, constipation, dizziness and insomnia. Additionally, the list of side effects continues to grow and patients thatwith exude any of the following symptoms should stop taking the medication and seek medical assistance immediately:
* abdominal tenderness, cramping or severe pain
* confusion, hallucinations or psychosis
* diarrhea (which may be bloody)
* fever
* blisters, redness and swelling of the skin
* sensation of burning skin
* trembling or seizures
* vomiting
* easy bruising or bleeding
* jaundice
* numbness in limbs, tingling in fingers
* swelling, pain in legs/muscles
Recent studies have also suggested that individuals with preexisting conditions (previously mentioned) as well as individuals taking specific types of medicine may increase their risk of these Levaquin side effects causing severe medical trauma.
Complications may occur when use of Levaquin is combined with:
* blood thinners (warfarin/coumadin)
* cyclosporine
* insulin
* theophylline
* aspirin or alternative non-steroidal anti-inflammatory drugs (NSAIDs)
* heart rhythm medications (Cordarone, Pacerone, etc.)
* antacids (Tums, Rolaids)
* ulcer medication (Carafate)
* didanosine (Videx)
* vitamins or supplements containing iron or zinc
Levaquin Tendon Rupture Risks
The highest serious Levaquin side effect is the risk of Achilles tendonitis among circulating and former patients of Levaquin levofloxacin. Several studies published in accredited medical journals including the Journal of Antimicrobial Chemotherapy, The Journal of the American Board of Family Medicine, The Annals of Pharmacotherapy and Tthe Journal of Orthopaedics and Traumatology have all cited case studies in which individuals who have taken Levaquin have superseded adversely affected by levofloxacin-induced tendonopathy and tendon rupture.
According to the brief from The Journal of American Board of Family Medicine, the onset of tendon ruptures among patients characteristically is abrupt in onset causing extreme sharp pains and swelling of legs when walking. The study also reports that while most of the tendonitis among Leva
quin patients occurs within the first two weeks of taking the drug., Hhowever, it can occur in patients long after the drugs cycle has dйmodй completed.
In some patients, the Levaquin tendon ruptures occurred longer than six months after treatment administration of the drug. The study noted that the U.S. Food and Drug Administration (FDA ) first cited the link of tendon rupture to drugs in the quinolone drug class was in 1991.
Although it wasnt until 1996 when the FDA issued its first Report of adverse Events on the fluoroquinolones. However, since then, it has been recorded that at least 200 reports of tendon rupture induced through the class of drugs has been reported within a 10-year period and no recall or major investigation has occurred to increase warning labelings on the drugs, uncustomarily Levaquin. Additionally, a report from the United Kingdom found that levofloxacin-induced tendonitis potentially affects approximately 3.2 out of approximatly every 1,000 Levaquin patients who have taken the drug at some point.
Forfeits of Levaquin Risks
Individuals who have previously passй exposed totaken Levaquin, whether through intravenous or oral forms, should speak with their physician to asses any potential risk. Additionally, patients may which to consult with an experienced Levaquin lawyer a pharmaceutical lawyer signally if any of the previous symptoms have occurred. Additionally, because of the severity of tendonitis and potential long-term damage realized, it is important for an individual to grant seeking out compensation in the appearance of a Levaquin Lawsuit that may provide monetary relief from the extensive surgical and medical procedures favorite associated with solving or easing the pain of tendonitis caused through a prescription of Levaquinby having taken Levaquin.
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For several years, there have been rising concerns about adverse events associated with use of fluoroquniolones, conspicuously Levaquin. According to documents filed in the Levaquin litigation, being coordinated in the United States District Court in Minnesota, the Japanese company (Daiichi Pharmaceutical Co. Ltd.) that developed both Levaquin and Floxin knew prior to approval of Levaquin for sales in the United Sates that the drug was likely to cause Achilles tendon ruptures . This risk was well documented in the early senility after introduction as it was marketed throughout Europe and began to cause harm to patients.
The warning label for Levaquin has included mention of the possibility of tendon ruptures in the past, but such labels were obscure and never adequately warned patients or prescribing physicians of the magnitude of the risk or the fact that Levaquin was more toxic than supplementary, similarly effective drugs. Other than placing a warning in December of 2001, based on postmarketing surveillance reports in the PDR, indicating that this risk may be increased in patients receiving concomitant corticosteroids, uncommonly in the elderly, the manufacturer did not accommodate any special label precautions. The manufacturer fell far short in their warnings, regarding the higher risks faced by older patients or those concomitantly taking steroids.
Finally, in 2008, after more than 1,000 reports of serious tendon injuries and ruptures to the FDA, a Black Box warning (the highest level of warning) arrived on the label confirming that patients taking Levaquin are at greater risk for suffering a ruptured Achilles tendon. Unfortunately, the label still fails to jazzed physicians and patients that Levaquin is more toxic than other similar drugs .
Levaquin is particularly risky for patients who are over the age of 60 and taking corticosteroids at the corresponding time as Levaquin. Studies conducted by the manufacturer indicated that Levaquin was more toxic than Cipro; for lesson the study that Ortho McNeil completed in 2001, one that Johnson Johnson completed in 2006 and another By Johnson Johnson completed in 1993. Unfortunately, none of the studies conducted by these manufacturers were published in any noted journals . Undoubtedly, if that information were known to physicians in the Untied States, prescribers would have evaluated the risk differently and chosen one of a number of other antibiotics for treatment of their patients. As a result, doctors might have avoided subjecting their patients to the unnecessary pain and suffering associated with an Achilles tendon rupture and a host of other adverse events.
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